Obstructive sleep apnoea was associated with a significantly lower mean peak oxygen consumption compared with controls (mean difference -2.7 mL·kg−1·min−1; p<0.001).
Meta-Analysis (n=850)
Does obstructive sleep apnoea reduce peak oxygen consumption compared to controls?
Patients with obstructive sleep apnoea have significantly reduced maximal aerobic capacity compared to controls, highlighting the potential utility of exercise testing to evaluate cardiovascular risk and functional limitation in this population.
Mean Difference: -2.7
p-value: p=<0.001
Maximal aerobic capacity is a strong health predictor and peak oxygen consumption ( V ′ O 2 peak ) is considered a reflection of total body health. No systematic reviews or meta-analyses to date have synthesised the existing data regarding V ′ O 2 peak in patients with obstructive sleep apnoea (OSA). A systematic review of English and French articles using PubMed/MEDLINE and Embase included studies assessing V ′ O 2 peak in OSA patients either in mL·kg −1 ·min −1 compared with controls or in % predicted. Two independent reviewers analysed the studies, extracted the data and assessed the quality of evidence. Mean V ′ O 2 peak expressed in mL·kg −1 ·min −1 was significantly lower in patients with OSA than in controls (mean difference −2.7 mL·kg −1 ·min −1 ; p<0.001; n=850). This reduction in V ′ O 2 peak was found to be larger in non-obese patients (body mass index <30 kg·m −2 ). Mean V ′ O 2 peak % pred was 89.9% in OSA patients (n=643). OSA patients have reduced maximal aerobic capacity, which can be associated with increased cardiovascular risks and reduced survival in certain patient subgroups. Maximal exercise testing can be useful to characterise functional limitation and to evaluate health status in OSA patients.
Mendelson et al. (Thu,) conducted a meta-analysis in Obstructive sleep apnoea (OSA) (n=850). Obstructive sleep apnoea vs. Controls was evaluated on Mean V'O2peak (mL·kg−1·min−1) (MD -2.7, p=<0.001). Obstructive sleep apnoea was associated with a significantly lower mean peak oxygen consumption compared with controls (mean difference -2.7 mL·kg−1·min−1; p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: