What is the clinical evidence from this study?

Study design: Observational. Population: Healthy (n=77). Intervention: Ovulatory and luteal phases of the ovarian-menstrual cycle vs. Follicular phase. Primary outcome: Mean blood pressure (BPm) in the prone position at rest (MD 2.76 mm Hg, p=<0.05).

April 16, 2017Open Access

Blood Pressure and Hemodynamics: Mayer Waves in Different Phases of Ovarian and Menstrual Cycle in Women

Q: What are the key findings of this study?

Mean blood pressure levels in the prone position at rest significantly increased in the luteal phase compared with the follicular phase by 2.76 mm Hg (P<0.05).

Key Result

Mean blood pressure levels in the prone position at rest significantly increased in the luteal phase compared with the follicular phase by 2.76 mm Hg (P<0.05).

Study Design

Type

Observational (n=77)

Multicenter

Structured PICO

Do different phases of the ovarian-menstrual cycle affect blood pressure levels and Mayer wave characteristics in healthy young women?

Population

77 healthy women aged 18-19 with regular ovarian-menstrual cycles were tested across follicular, ovulatory, and luteal phases to assess blood pressure and Mayer wave characteristics.

Exposure

Observation during ovulation (phase II) and luteal phase (phase III) of the ovarian-menstrual cycle, evaluated in prone position at rest, during tilt test, and with psycho-emotional loading.

Comparator

Observation during the follicular phase (phase I) of the same ovarian-menstrual cycle.

Outcome

Changes in systolic, diastolic, and mean blood pressure, and characteristics of Mayer waves (R-R interval duration and stroke volume oscillations in the 0.04-0.15 Hz range).surrogate

Mean and diastolic blood pressure, along with sympathetic tone, increase during the ovulatory and luteal phases of the menstrual cycle in healthy young women, correlating with changes in spontaneous baroreflex sensitivity.

Main Result

Mean Difference: 2.76

p-value: p=<0.05

Limitations

Measurements were performed on a fairly limited (in age, social background) contingent
Examined women had normal blood pressure, making it problematic to generalize results to individuals with blood pressure disorders

Abstract

The goal of the research is to investigate the special effect of ovarian-menstrual cycle phases on the level of women's blood pressure and characteristics of Mayer waves. 77 women aged 18-19 were tested under condition close to the state of basal metabolism in follicular phase (I), ovulation (II) and luteal phase (III) of ovarian-menstrual cycle. In phases II and III, the increase of mean and diastolic blood pressure level, in comparison with phase I in the prone position at rest and with psycho-emotional loading, were observed. The distinctions between variation parameters of R-R interval duration, stroke volume and its synchronization in phases II and III, in comparison with phase I, were observed in the prone position at rest, during tilt-test and with psycho-emotional loading. The substantial level of relationship between the power of Mayer waves and mean and diastolic blood pressure, mainly in phase I under conditions of all types, is observed. The maximum peak amplitude of stroke volume spectrogram is associated with pressure levels in the range of 0.04-0.15 Hz (rho from -0.33 to -0.64). The obtained results indicate the possible participation of spontaneous baroreflex sensitivity characteristics in keeping blood pressure level in women.

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