Alcohol withdrawal and detoxification in persons with alcohol use disorder was associated with variations in arterial stiffness and worsened lipid profiles, particularly in older women and younger men.
Observational (n=241)
Does alcohol withdrawal and detoxification influence arterial stiffness and classical risk factors for cardiovascular disease in persons with alcohol use disorder?
Alcohol withdrawal and detoxification in persons with alcohol use disorder may transiently worsen lipid profiles and alter arterial stiffness, suggesting a need for cardiovascular monitoring during therapy.
AIMS: The amount and pattern of cigarette and alcohol consumption are highly associated with cardiovascular risk. The aim of the present study was the assessment of changes in arterial stiffness and classical risk factors for cardiovascular disease after alcohol withdrawal and detoxification in persons with alcohol use disorder. METHODS: Two hundred and forty-one individuals (men and women) participated in the investigation. The photoplethysmographic method was applied to assess arterial stiffness in three stages within 6 weeks. Participants were divided into subgroups based on age and sex. Analyses were performed using analysis of variance with repeated measures. RESULTS: Different variations in time of stiffness index (SI) and reflection index (RI) values were recorded. Some increases in triglycerides, total cholesterol, low-density lipoprotein and a decrease in high-density lipoproteins were observed in all analyzed groups. Both systolic and diastolic blood pressure (DP) changed significantly during the 3 weeks of the study only in a group of younger men. The SI is correlated with age and gender. No correlation of RI with sex was found; however, RI was strongly correlated with age, pulse and DP. CONCLUSIONS: The presented study shows that some groups of patients (older women and younger men) after detoxification may be particularly vulnerable to vascular system disorders, i.e. arterial stiffness, making it suggested to include additional observation during therapy.
Szołtysek-Bołdys et al. (Mon,) conducted a observational in Alcohol use disorder (n=241). Alcohol withdrawal and detoxification was evaluated on Changes in arterial stiffness (stiffness index and reflection index) and classical risk factors for cardiovascular disease. Alcohol withdrawal and detoxification in persons with alcohol use disorder was associated with variations in arterial stiffness and worsened lipid profiles, particularly in older women and younger men.