Time-averaged wall shear stress was positively correlated with normalized wall index (r=0.592, p<0.05), whereas oscillatory shear index was negatively correlated (r=-0.310, p<0.01).
Observational (n=6)
Is there an association between time-averaged wall shear stresses (TAWSS), oscillatory shear index (OSI), and atherosclerotic burden (NWI) in the superficial femoral artery of patients with peripheral artery disease?
In patients with peripheral artery disease, MRI-based hemodynamic assessment of the superficial femoral artery is feasible and shows that time-averaged wall shear stress is positively associated with plaque burden, while oscillatory shear index is inversely associated.
Effect estimate: r = 0.592 for TAWSS; r = -0.310 for OSI
p-value: p=< 0.05 for TAWSS; < 0.01 for OSI
BACKGROUND AND AIMS: MRI-based hemodynamics have been applied to study the relationship between time-averaged wall shear stresses (TAWSS), oscillatory shear index (OSI) and atherosclerotic lesions in the coronary arteries, carotid artery, and human aorta. However, the role of TAWSS and OSI are poorly understood in lower extremity arteries. The aim of this work was to investigate the feasibility of hemodynamic assessment of the superficial femoral artery (SFA) in patients with peripheral artery disease (PAD) and we hypothesized that there is an association between TAWSS and OSI, respectively, and atherosclerotic burden expressed as the normalized wall index (NWI). METHODS: Six cases of 3D vascular geometries of the SFA and related inlet/outlet flow conditions were extracted from patient-specific MRI data including baseline, 12 and 24 months. Blood flow simulations were performed to compute flow descriptors, including TAWSS and OSI, and NWI. RESULTS: NWI was correlated positively with TAWSS (correlation coefficient: r = 0.592; p < 0.05). NWI was correlated negatively with OSI (correlation coefficient: r = -0.310, p < 0.01). Spatially averaged TAWSS and average NWI increased significantly between baseline and 24-months, whereas OSI decreased over 2-years. CONCLUSIONS: In this pilot study with a limited sample size, TAWSS was positively associated with NWI, a measure of plaque burden, whereas OSI showed an inverse relationship. However, our findings need to be verified in a larger prospective study. MRI-based study of hemodynamics is feasible in the superficial femoral artery.
Singh et al. (Wed,) conducted a observational in Peripheral artery disease (PAD) (n=6). Time-averaged wall shear stresses (TAWSS) and oscillatory shear index (OSI) was evaluated on Correlation between TAWSS/OSI and normalized wall index (NWI) (r = 0.592 for TAWSS; r = -0.310 for OSI, p=< 0.05 for TAWSS; < 0.01 for OSI). Time-averaged wall shear stress was positively correlated with normalized wall index (r=0.592, p<0.05), whereas oscillatory shear index was negatively correlated (r=-0.310, p<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: