Aerobic exercise reverses impairments in endothelial L-arginine transport and improves endothelial function in chronic kidney disease by increasing nitric oxide bioavailability.
Does aerobic exercise improve endothelial function in patients with chronic kidney disease?
Aerobic exercise may reverse endothelial dysfunction in chronic kidney disease by improving L-arginine transport and increasing nitric oxide bioavailability.
In Brief Endothelial dysfunction occurs in chronic kidney disease (CKD) and increases the risk for cardiovascular disease. The mechanisms of endothelial dysfunction seem to evolve throughout kidney disease progression, culminating in reduced L-arginine transport and impaired nitric oxide bioavailability in advanced disease. This review examines the hypothesis that aerobic exercise may reverse endothelial dysfunction by improving endothelial cell L-arginine uptake in CKD. Exercise reverses impairments in endothelial L-arginine transport and improves endothelial function in chronic kidney disease by increasing nitric oxide bioavailability.
Martens et al. (Wed,) conducted a review in Chronic kidney disease. Aerobic exercise was evaluated on Endothelial function and L-arginine transport. Aerobic exercise reverses impairments in endothelial L-arginine transport and improves endothelial function in chronic kidney disease by increasing nitric oxide bioavailability.