Semiautomated 4D flow MRI analysis demonstrated good reproducibility and detected significant differences in descending aorta peak velocities between congenital and tricuspid aortic valves (P=0.014).
Observational (n=20)
Does a semiautomated workflow for aortic 4-dimensional flow MRI accurately detect hemodynamic differences in patients with aortic dilatation compared to manual segmentation?
A semiautomated workflow for 4D flow MRI analysis of aortic hemodynamics offers good reproducibility and accuracy with reduced analysis time compared to manual segmentation.
p-value: p=0.014
OBJECTIVE: The aim of this study was to systematically investigate a newly developed semiautomated workflow for the analysis of aortic 4-dimensional flow MRI and its ability to detect hemodynamic differences in patients with congenitally altered aortic valve (bicuspid or quadricuspid valves) compared with tricuspid aortic valves. METHODS: Four-dimensional flow MRI data were acquired in 20 patients with aortic dilatation (9 tricuspid aortic valves, 11 congenitally altered aortic valves). A semiautomated workflow was evaluated regarding interobserver variability, accuracy of net flow, regurgitant fraction and peak systolic velocity, and the ability to detect differences between cohorts. Results were compared with manual segmentation of vessel contours. RESULTS: Despite the significantly reduced analysis time, a good interobserver agreement was found for net flow and peak systolic velocity, and a moderate agreement was found for regurgitation. Significant differences in peak velocities in the descending aorta (P = 0.014) could be detected. CONCLUSIONS: Four-dimensional flow MRI-based semiautomated analysis of aortic hemodynamics can be performed with good reproducibility and accuracy.
Schnell et al. (Wed,) conducted a observational in Aortic dilatation with congenital or tricuspid aortic valves (n=20). Semiautomated 4D flow MRI analysis vs. Manual segmentation and tricuspid aortic valves was evaluated on Interobserver variability, accuracy of hemodynamic parameters, and detection of cohort differences (p=0.014). Semiautomated 4D flow MRI analysis demonstrated good reproducibility and detected significant differences in descending aorta peak velocities between congenital and tricuspid aortic valves (P=0.014).