Preparation Methods and Pharmaceutical Significances of Emulgel dosage form: A Review

Emulgels are a novel type of pharmaceutical formulation developed by combining emulsions and gels. The present review was based on the preparation methods and pharmaceutical significances of emulgel dosage form: a review. When designing the product, it is essential to evaluate the topical emulgel for its lack of toxicity, irritation, comedogenicity, and sensitization. Penetration enhancers can work through one or more of 3 mechanisms i.e., destruction of the highly ordered lipid structure of the stratum corneum, interaction with extracellular proteins and better penetration of the drug, activator or solvent into the stratum corneum. The purpose of these substances is to improve the transdermal administration of the medication. The type and concentration of the penetration enhancer can have a big impact on how well a medicine penetrates from an emulgel. The procedure for creating emulgel consists of three simple steps. The initial two stages involve the separate formation of the emulsion and gel base. It illustrates the fundamental stages involved in the preparation of emulgel. The process of gel phase preparation entails dispersing gelling agents, such as carbopol or HPMC, into distilled water. To produce emulgel, the emulsion and gel phases are mixed together in a 1:1 ratio with gentle stirring. In conclusion, Emulgel is a new topical drug delivery method that works better with hydrophobic medications and is clearly superior when used with hydrophilic and lipophilic medications. Similar to Emulgel, it can enhance diffusion, adhesion, viscosity, and extrusion; this novel therapeutic approach has gained widespread popularity.