Abstract Amiodarone hydrochloride (AD), a Class II antiarrhythmic agent, is widely prescribed for ventricular and supraventricular arrhythmias. However, its limited aqueous solubility constrains its clinical application. In this study, two chemically stable AD nanosuspensions were prepared via the evaporative precipitation into aqueous solution (EPAS) method and the wet-milling technique. The nanosuspensions were characterised by transmission electron microscopy, photon correlation spectroscopy, differential scanning calorimetry (DSC), and X-ray powder diffraction (XRPD). DSC and XRPD analyses confirmed the maintenance of the crystalline state. In vitro dissolution assays demonstrated that both nanosuspensions exhibited significantly improved dissolution rates compared with their coarse suspension counterparts. Pharmacokinetic studies in rats showed that the oral bioavailability of AD in nanosuspensions (75.91 and 64.72%) was two to three times higher than that of coarse suspensions (33.31%).
You et al. (Thu,) studied this question.
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