ARVC patients exhibited significantly more abnormal 12-lead ECGs (62% vs 7.5%, p<0.0001) and larger right ventricular outflow tracts compared to athletes, aiding in differential diagnosis.
Cross-Sectional (n=120)
Does clinical and non-invasive instrumental evaluation distinguish arrhythmogenic right ventricular cardiomyopathy from physiological athlete's heart adaptations?
Clinical and non-invasive instrumental evaluation, particularly echocardiography and ECG, can effectively distinguish right ventricular alterations typical of ARVC from physiological adaptations in athletes.
Absolute Event Rate: 62% vs 7.5%
p-value: p=<0.0001
BACKGROUND: Regular intensive physical activity is associated with non-pathological changes in cardiac morphology. Differential diagnosis with arrhythmogenic right ventricular cardiomyopathy (ARVC) constitutes a frequent problem, especially in athletes showing ventricular arrhythmias with left bundle branch block morphology. AIM OF THE STUDY: To assess the different clinical and non-invasive instrumental features of the subjects affected by ARVC and by athletes. METHODS: Three groups of subjects (40 ARVC patients, 40 athletes and 40 controls, mean age 27 (9) years) were examined with family and personal history, physical examination, 12-lead ECG, 24-h ECG, signal-averaged ECG and 2-D and Doppler echocardiography. RESULTS: 12-Lead ECG was abnormal in 62% of ARVC patients versus 7.5% of athletes and 2.5% of controls (p<0.0001). Ventricular arrhythmias and late potentials were present in 70% and 55% of ARVC subjects, respectively (vs 5% of athletes and 7.5% of controls, p<0.0001). Left ventricular parietal wall thickness and left ventricular end-diastolic diameters were significantly higher in athletes. Both athletes and ARVC patients presented a right ventricular (RV) enlargement compared with controls. Moreover, RV outflow tract, measured on parasternal long axis and at the level of aortic root, was significantly larger in ARVC patients (33.6 (4.7) mm vs 29.1 (3.4) mm and 35.6 (6.8) mm vs 30.1 (2.9) mm; p<0.0001), and RV fractional shortening and ejection fraction were significantly lower in ARVC patients compared with athletes (40 (7.9)% vs 44 (10)%; p=0.05 and 52.9 (8)% vs 59.9 (4.5)%; p<0.0001). A thickened moderator band was found to be present in similar percentage in ARVC patients and athletes. CONCLUSIONS: An accurate clinical and instrumental non-invasive evaluation including echocardiography as imaging technique allows to distinguish RV alterations typical of ARVC from those detected in athletes as a consequence of intensive physical activity.
Bauce et al. (Fri,) conducted a cross-sectional in Arrhythmogenic right ventricular cardiomyopathy (ARVC) and athlete's heart (n=120). Arrhythmogenic right ventricular cardiomyopathy (ARVC) vs. Athletes and healthy controls was evaluated on Abnormal 12-lead ECG (p=<0.0001). ARVC patients exhibited significantly more abnormal 12-lead ECGs (62% vs 7.5%, p<0.0001) and larger right ventricular outflow tracts compared to athletes, aiding in differential diagnosis.