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Dysfunctional adipose tissue in obesity releases factors such as adipokines and lipids that drive peripheral and central neuroinflammation, disrupting the blood-brain barrier and synaptic plasticity to cause chronic pain sensitization and cognitive deficits. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Adipose Tissue and Central Nervous System Crosstalk: Roles in Pain and Cognitive Dysfunction

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