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Finding the needle in the haystack: A dynamic combinatorial library (DCL) of peptides was created using the disulfide-exchange reaction of cysteines. Three cyclic peptides were found to be selective receptors for carbohydrates in water. One of these, HisHis, formed preferentially in a DCL in the presence of the neurotransmitter NANA.
Rauschenberg et al. (Thu,) studied this question.
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