Pancreatic fat deposition was significantly higher in individuals with abnormal glucose metabolism and served as a reliable indicator of the condition (AUC 0.859 in normal weight, 0.864 in overweight).
Cross-Sectional (n=98)
Does abdominal ectopic fat distribution measured by MRI correlate with abnormal glucose metabolism?
MRI-quantified pancreatic fat deposition is strongly associated with abnormal glucose metabolism and may serve as a reliable indicator of metabolic risk.
Effect estimate: AUC 0.859 and 0.864
INTRODUCTION: The purpose of this study was to compare the difference in abdominal fat distribution between different metabolic groups and find the ectopic fat with the most risk significance. METHODS: A total of 98 subjects were enrolled; there were 53 cases in the normal glucose metabolism group and 45 cases in the abnormal glucose metabolism group. Chemical shift-encoded magnetic resonance imaging was applied for quantification of pancreatic fat fraction (PFF) and hepatic fat fraction (HFF), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT). The correlation and the difference of fat distribution between different metabolism groups were analyzed. The receiver operating characteristic (ROC) curve was used to analyze the suggestive effect of different body fat fraction. RESULTS: Correlation analysis showed that body mass index (BMI) had the strongest correlation with fasting insulin (r = 0.473, p < 0.001), HOMA-IR (r = 0.363, p < 0.001), and C-reactive protein (r = 0.245, p < 0.05). Pancreatic fat has a good correlation with fasting blood glucose (r = 0.247, p < 0.05) and HbA1c (r = 0.363, p < 0.001). With the increase of BMI, PFF, VAT, and SAT showed a clear upward trend, but liver fat was distributed relatively more randomly. The pancreatic fat content in the abnormal glucose metabolism group is significantly higher than that in the normal group, and pancreatic fat is also a reliable indicator of abnormal glucose metabolism, especially in the normal and overweight groups (the area under the curve was 0.859 and 0.864, respectively). CONCLUSION: MR-based fat quantification techniques can provide additional information on fat distribution. There are differences in fat distribution among people with different metabolic status. People with more severe pancreatic fat deposition have a higher risk of glucose metabolism disorders.
Li et al. (Mon,) conducted a cross-sectional in Abnormal glucose metabolism (n=98). Abdominal ectopic fat (pancreatic fat) vs. Lower fat deposition was evaluated on Indicator of abnormal glucose metabolism (AUC 0.859 and 0.864). Pancreatic fat deposition was significantly higher in individuals with abnormal glucose metabolism and served as a reliable indicator of the condition (AUC 0.859 in normal weight, 0.864 in overweight).