Type 2 diabetes mellitus was associated with significantly higher levels of circulating total microparticles compared to non-diabetic controls (SMD 0.64; 95% CI 0.12-1.15; P=0.02).
Meta-Analysis (n=4,340)
Are circulating cell-derived microparticles elevated in patients with type 2 diabetes mellitus compared to non-diabetic controls?
Circulating cell-derived microparticles, particularly those derived from platelets, monocytes, and endothelium, are significantly elevated in patients with type 2 diabetes mellitus.
Standardized Mean Difference: 0.64 (95% CI 0.12–1.15)
p-value: p=0.02
BACKGROUND/AIMS: The aim of this study was to assess the association between circulating cell-derived microparticles (MPs) and type 2 diabetes mellitus (T2DM). METHODS: A literature search was performed systematically in PubMed and Embase to identify available case-control or cross-sectional studies that compared different types of cell-derived MPs in patients with T2DM and non-diabetic controls. Pooled standardized mean differences (SMDs) of each MP type were pooled using meta-analysis. RESULTS: Forty-eight studies involving 2,460 patients with T2DM and 1,880 non-diabetic controls were included for systematic review and 34 of which were included for quantitative study by meta-analysis. In the overall analysis, the levels of circulating total MPs (TMPs), platelet-derived MPs (PMPs), monocyte-derived MPs (MMPs) and endothelium-derived MPs (EMPs) were significantly higher in T2DM patients than those in controls (TMPs: SMD, 0.64; 95%CI, 0.12∼1.15; P=0.02; PMPs: SMD, 1.19; 95%CI, 0.88∼1.50; P <0.00001; MMPs: SMD, 0.92; 95%CI, 0.66∼1.17; P <0.00001; EMPs: SMD, 0.73; 95%CI, 0.50∼0.96; P <0.00001). Meanwhile, no significant difference was shown in leukocyte-derived MPs (LMPs) level between diabetic and non-diabetic groups (SMD, 0.37; 95%CI, -0.15∼0.89; P=0.17). CONCLUSIONS: The counts of TMPs, PMPs, MMPs and EMPs elevated in patients with T2DM. And cell-derived MPs may play a role in the pathogenesis of T2DM.
Li et al. (2016) conducted a meta-analysis in Type 2 Diabetes Mellitus (n=4,340). Type 2 Diabetes Mellitus vs. Non-diabetic controls was evaluated on Levels of circulating total microparticles (TMPs) (SMD 0.64, 95% CI 0.12-1.15, p=0.02). Type 2 diabetes mellitus was associated with significantly higher levels of circulating total microparticles compared to non-diabetic controls (SMD 0.64; 95% CI 0.12-1.15; P=0.02).