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lead to water losses, such as diabetes.The patient's low level of consciousness was thought at first to be due to buprenorphine, while the other signs were attributed to septicaemia.Hypernatraemia is managed by giving 5°,', dextrose to bring the plasma sodium concentration down to the normal range, taking care not to produce water intoxication.Cerebral oedema may follow over- rapid dilution of plasma at a time when the brain cells have a high sodium content.These patients usually have a pronounced diuresis with a large sodium output due to the hyperosmolality of plasma, and diuretics are not needed.3Because of massive diuresis they also lose potassium, which will need replacement.
Wright et al. (1982) studied this question.