Older age (61-70 years) was associated with significantly lower early diastolic mitral peak flow velocity (45 vs 66 cm/s, P<0.01) compared to younger age (21-30 years).
Cross-Sectional (n=66)
How do age, body surface area, gender, and blood pressure affect pulsed Doppler transmitral flow velocity measurements in normal subjects?
Age and systolic blood pressure significantly affect pulsed Doppler transmitral flow velocity parameters, which must be accounted for when evaluating left ventricular filling.
Absolute Event Rate: 45% vs 66%
p-value: p=<0.01
The effects of age, body surface area, gender, and blood pressure on pulsed Doppler transmitral flow velocity measurements were evaluated in 66 adult men and women, ages 21-78 years, without a history of hypertension or cardiovascular disease. Measurements were made at the level of the mitral leaflet tips of early and late diastolic transmitral peak flow (filling) velocities, flow times and flow velocity integrals, and of early diastolic flow acceleration and deceleration. Mitral peak flow velocity in early diastole (PFVE) was significantly lower (p 0.65, p < 0.001) with systolic blood pressure. There was no significant relationship between any of the Doppler mitral flow parameters and body surface area, diastolic blood pressure, or gender. Age-related changes in pulsed Doppler transmitral flow velocity parameters must be taken into account when evaluating patients with suspected alterations in left ventricular filling.
Gardin et al. (2017) conducted a cross-sectional in Normal subjects (n=66). Older age (61-70 years) vs. Younger age (21-30 years) was evaluated on Mitral peak flow velocity in early diastole (PFVE) (p=<0.01). Older age (61-70 years) was associated with significantly lower early diastolic mitral peak flow velocity (45 vs 66 cm/s, P<0.01) compared to younger age (21-30 years).