July 28, 2025

Evaluation Of Epidemiology Bacterial Infectious Diseases In Mosul General Hospital With Survey Of Clinical Features And Immunological Criteria For Septicemia In ICU-Patients

MYMahmood Y YounisUniversity of Mosul HAHaider AltaiiCleveland Clinic HDH. DaherUniversity of Mosul

Key Points

Main finding showed that 50.67% of samples tested positive for bacterial infections, with distinct Gram-positive and Gram-negative rates.
Clinical assessments revealed significant differences in immunological parameters, indicating their role in septicemia diagnosis.
The research utilized a wide sample range (1,480), involving diverse patient demographics across various hospital departments.
Identifying effective antibiotics for Gram-positive and Gram-negative bacteria can enhance treatment strategies for septicemia.

Abstract

Abstract PurposeThe research was performed on patients hospitalized to all departments of Mosul General Hospital in Nineveh Governorate, Iraq and aimed to evaluate the epidemiology of bacterial infectious diseases. Determine the antibiotic resistance profiles and minimum inhibitory concentrations (MICs) of isolates using the Vitek-2 compact system. Study clinical features and some immunological parameters (IgM, IgG, hs-CRP, WBCs and D-dimer) in intensive care unit (ICU) patients with and without septicemia.MethodA total of 1,480 samples (Blood, Urine, Stool, High Vaginal Swab, Pus and Sputum) from both sexes and different ages groups, were collected during this investigation from the first of January 2023, to October 2024.ResultThe results indicated that 730/1480(49.33%) samples revealed negative cultures and 750/1480 (50.67%) sample revealed positive cultures consisting of 374/750(49.87%) Gram-positive bacteria and 376/750(50.13%) Gram-negative bacteria. Antimicrobial susceptibility testing showed that Vancomycin, linezolid, imipenem, tetracycline and tigecycline are the best antibiotics against Gram-positive bacteria. In contrast, ceftazidime/avibactm, ceftolozane/tazobactam, meropenem, imipenem and colistin had the best antibacterial effect against most Gram-negative bacteria. The results of the ELISA, CBC Sysmex device and Mini-vidas technique revealed elevated levels of IgM, IgG, hs-CRP, White blood cells (WBCs) count and D-dimer in septicemia patients and non-septicemia patients compared with healthy control group high significant difference P-value (ConclusionsIgM, IgG, hs-CRP, WBCs and D-dimer levels were significantly different in sepsis patients. Staphylococcus aureus and E coli were predominant and still the causative agents. Vancomycin, linezolid, imipenem, tetracycline and tigecycline are the best antibiotics against Gram-positive bacterial strains. In contrast, ceftazidime/avibactm, ceftolozane/tazobactam, meropenem, imipenem and colistin had the best antibacterial effect against most Gram-negative bacterial isolates

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