With the growing variety of pharmacological compounds and the increasing need for polypharmacy, accurately predicting drug-drug interactions (DDIs) is essential to ensure both treatment efficacy and patient safety. Beneficial DDIs can enhance therapeutic outcomes. In contrast, adverse interactions may result in toxicity, reduced efficacy, or even fatality. Thus, the accurate prediction of DDIs is paramount. Building on recent advancements in graph neural network (GNN) architectures, this paper extends prior research, such as the SAGE GNN model, Graph Attention Network model, and Graph Diffusion Network model, by integrating advanced techniques such as skip connections, post-processing layers, and optimized training methods. It start from basic GNN to buld more advanced models such as based on Adaptive Graph Diffusion model. Our experimental results shows based on evaluation on 3 different drug-drug interaction dataset that on some evaluation metric basic models outperforms the advanced ones. We have found that GCN with skip connections, GCN with NGNN and SAGE with NGNN give competent accuracy with other baseline models. The corresponding code and datasets used in this study are available on GitHub for reproducibility at: https://github.com/khushnood/DrugDruginteractionPredictionBasedOnGNN .
Abbas et al. (Tue,) studied this question.