Abstract In the presence of chiral palladium complexes, the enantioselective catalytic Suzuki–Miyaura reaction of meso diboryltetrahydronaphthalene was found to occur with chain-walking. This process provides access to compounds with a 1,3 relationship between the cross-coupled aryl group and the remaining boronic ester. The reaction was applied toward the synthesis of pharmaceutically relevant targets and provides a simple inroad to enantiomerically enriched materials.
Lee et al. (Wed,) studied this question.