Synthesis, evaluation of in vitro cytotoxic activity, and in silico studies of some 3-methylenamino-4(3H)-quinazolone derivatives

Key Points

• Compounds 5, 6, and 7 exhibited significant cytotoxic effects against RD and MDA-MB-231 cells, with low toxicity to normal cells.
• Cytotoxicity results showed strong binding to EGFR, indicating potential for targeted cancer treatments in future studies.
• Twenty novel quinazolone derivatives were synthesized through imine formation, demonstrating promise for cancer applications.
• Good ADMET profiles suggest these derivatives may lead to viable therapeutic options, yet further studies are warranted.