(1) Aims: This review aims to investigate whether screen-based simulated learning experiences improve on traditional teaching strategies to bridge the theory–practice gap for biomedical scientists and enhance the readiness to practice of graduates. (2) Methods: This review adheres to the systematic–narrative hybrid literature review strategy with the scope of review defined according to Cochrane guidelines for systematic reviews. To identify the potentially relevant literature, the PUBMED, CINAHL, and Web of Science bibliographic databases were searched using the identified keywords from January 2020 to February 2025. Thematic analysis of the resultant literature was conducted in line with the Braun and Clarke framework. (3) Results: The original search and analysis of the online databases returned 45 papers. Collectively these sources explore global perspectives on biomedical science education, training, and professional practice. These include the identification of core competencies that may contribute to the theory–practice gap for biomedical scientists, as well as educational interventions that aim to address them. The poor quality of existing research on simulation-based learning, mostly from academic settings, makes it challenging to apply the findings to professional practice. This limitation is primarily due to an overreliance on self-reported data and perceived learning gains rather than direct, objective evaluations of competence. Future studies should focus on objective, validated outcome measures and longitudinal follow-up to assess real-world impacts and learning transfer. (4) Conclusions: Simulation-based learning experiences have the potential to address aspects of the theory–practice gap for biomedical scientists, but the current evidence base reflects a lack of understanding regarding specific targets and strategies for its design, evaluation, and integration in this context. There is a need for more robust evidence that evaluates their impacts on readiness to practice. This need is hindered by a lack of research directly investigating the impact of simulation-based teaching and training interventions in clinical settings.
Rouse et al. (Thu,) studied this question.