Figure S9 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Key Points

• Alterations in gene expression linked to epithelial-mesenchymal transition were observed with PPARδ knockdown, revealing a role in metastasis.
• Key findings indicate a connection between PPARδ activity and metabolic changes in pancreatic cancer derived xenografts.
• The study utilizes patient-derived xenografts (PDXs) to assess metabolic responses influenced by microenvironmental factors.
• Results highlight the importance of PPARδ in orchestrating a prometastatic metabolic response in pancreatic cancer.