Abstract Background: Medulloblastoma, the most common malignant pediatric brain tumor, has distinct molecular subtypes that vary in prognosis and treatment response. Accurate preoperative identification of these subtypes is crucial for optimizing therapy. Objective: The aim of our study was to differentiate medulloblastoma molecular subtypes using multiparametric MRI, including MRI-based texture analysis. Materials and methods: Fifty-eight patients with preoperative MRI and histopathological diagnoses of medulloblastoma were included. The patients were divided into SHH pathway active and group 3/group 4 subtypes. Morphological MRI findings, ADC measurements, and texture analysis features were compared between the groups. Results: Of the 58 patients, 55.2% had SHH-active tumors. Morphological features, including location out of the midline or in the cerebellar hemisphere (pConclusion: Combining MRI morphological findings, ADC measurements, and texture analysis offers valuable diagnostic information for distinguishing medulloblastoma molecular subtypes.
Aslan et al. (Wed,) studied this question.