What type of study is this?

This is a Quasi-Experimental study.

September 10, 2025

Role of Activated Charcoal in Mitigating Lead-Induced Hepatotoxicity in Albino Wistar Rats

Key Points

Activated charcoal significantly reduces lead-induced hepatotoxicity in albino Wistar rats, improving liver function tests.
Blood analysis showed Group B had elevated liver enzymes and bilirubin levels, while Group C had intermediate values.
This quasi-experimental study involved three groups of male Wistar rats, assessing biochemical and histopathological parameters.
Findings suggest activated charcoal may mitigate inflammation and oxidative stress associated with lead exposure.

Abstract

Background: Lead is a pervasive environmental toxin known for its severe impact on human health, particularly targeting vital organs like the liver through mechanisms involving oxidative stress and inflammation. This study was conducted to evaluate the hepatoprotective effects of activated charcoal against lead-induced hepatotoxicity in albino Wistar rats. Methods: This quasi-experimental study was conducted from Feb to Aug 2024. Thirty-six male albino Wistar rats were divided into 3 groups (n=12): Group A (control group); Group B (lead-acetate group); and Group C (lead-acetate+activated charcoal group). Blood samples were collected by cardiac puncture and analysed for liver function tests. Liver tissues were harvested for histopathological analysis under high power after H21(2):29-33, DOI: https://doi.org/10.69656/pjp.v21i2.1761

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