Hepatoid adenocarcinoma of stomach is a rare and clinically aggressive tumor. Most of these cases are associated with increased production of alpha fetoprotein, but not all AFP producing tumors have hepatoid features histologically. We report a case of 64 years male, with elevated Alpha Fetoprotein levels. The patient underwent gastrectomy. HPE suggested a diagnosis of hepatoid adenocarcinoma. PAS staining also revealed PAS positive hyaline globules.
Raina et al. (Sun,) studied this question.