Motivation: The invasive nature of cardiopulmonary hemodynamic assessments leaves a gap in accessibility of diagnostic tools in fragile chronically ill patients with pulmonary hypertension. Goal(s): Understanding the complex interplay between hyperpolarized (HP) xenon-129 MRSI and cardiopulmonary hemodynamics, in non-invasive assessment of disease progression and treatment response. Approach: Vasoactive interventions were conducted on seven pigs, comparing invasive cardiopulmonary measurements with HP xenon-129 MRSI dissolved-phase and cardiogenic oscillations. Results: Interventions successfully caused vasoactive hemodynamic changes, detectable by HP 129Xe MRSI. An inverse proportional correlation was found between mPAP and oscillation amplitude, RBC AUC and RBC:mem. Impact: Hyperpolarized 129Xe MRSI enables non-invasive monitoring of pulmonary hypertension, facilitating early diagnosis and precise hemodynamic assessment. This approach supports optimized treatment, reduces hospitalizations, and enhances quality of life and survival in chronically ill patients.
Andersen et al. (Tue,) studied this question.