What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Motion-robust accelerated in vivo CEST MRI of perirenal fat with keyhole k-space acquisition

Key Points

This technique reduces scan time by four times, enhancing patient comfort during imaging procedures.
No significant differences in metabolic measurements were observed, suggesting consistent accuracy with conventional methods.
The integrated motion correction techniques address challenges posed by respiratory movement in imaging.
This advancement may provide better understanding of adipose tissue's role in metabolic disorders like obesity.

Abstract

Motivation: Quantifying creatine metabolism in perirenal fat offers insights into adipose tissue's role in energy regulation and metabolic disorders, but respiratory motion and organ displacement make reliable imaging challenging. Goal(s): To develop a motion-robust method for accelerated CEST MRI quantification of creatine in perirenal fat. Approach: Integrated three techniques: Savitzky-Golay filtering for spectral smoothing, Low-Rank Approximation of Z-spectra (LRAZ) for motion correction, and keyhole k-space reconstruction for faster acquisition. Results: The method achieved 4 times reduction in scan time while maintaining measurement accuracy, with no significant differences (p>0.05) in CrCEST effects compared to conventional full k-space acquisition. Impact: This novel integration of motion correction techniques with accelerated acquisition enables motion-robust in vivo CrCEST imaging of perirenal fat, potentially advancing our understanding of adipose tissue metabolism in obesity-related disorders while significantly reducing patient scan times.

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