What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Evaluation of Renal Perfusion and Oxygenation Characteristics in Patients with Sickle Cell Disease: Preliminary Findings

Key Points

Renal perfusion in sickle cell disease patients was significantly lower than in chronic kidney disease patients.
T2* and R2* values in the renal cortex of sickle cell patients were lower compared to healthy volunteers and chronic kidney disease patients.
Quantitative MRI techniques using ASL and BOLD provided important insights into kidney function in sickle cell disease.
The findings highlight the potential for noninvasive monitoring of kidney health in patients with sickle cell disease.

Abstract

Motivation: Chronic kidney disease (CKD) is a major cause of morbidity and mortality in patients with sickle cell disease (SCD). Goal(s): To evaluate quantitative MRI in SCD patients and compare against healthy volunteers (HV) and CKD patients without SCD. Approach: SCD (n=6), CKD (n=7), and HV (n=6) imaged with ASL (perfusion) and BOLD (oxygenation). Results: In SCD, (i) perfusion was statistically lower than CKD (P=0.01) but not different from HV (P=0.07); (ii) T2* (and R2*) in cortex were significantly lower (and higher) than HV and CKD (P<0.001); and (iii) T2* (and R2*) in medulla were substantially lower (and higher) compared to CKD (P<0.001). Impact: Noninvasive, non-contrast ASL measured perfusion and BOLD measured T2* and R2* provide early functional characterization of kidneys that could facilitate longitudinal monitoring and therapeutic interventions in patients with sickle cell disease (SCD).

AI에게 질문

Bookmark

View Full Paper