Motivation: Optimal diffusion-weighted imaging (DWI) sequence selection for breast lesion characterization remains challenging, with various techniques offering different advantages. Goal(s): To comprehensively compare three DWI techniques (A-ZOOMit DWI, SMS rs-EPI DWI, and ss-EPI DWI) for breast lesion evaluation at 3T MRI. Approach: In this prospective study of 68 patients with suspicious breast lesions, three experienced observers evaluated quantitative metrics and qualitative parameters using standardized assessment criteria. Results: A-ZOOMit DWI demonstrated superior measurement precision (AUC=0.92) and image quality, while SMS rs-EPI DWI excelled in periareolar regions. Each sequence showed distinct advantages for specific clinical scenarios, providing evidence-based guidance for protocol optimization. Impact: This evidence-based comparison enables optimized protocol selection for breast DWI based on specific clinical needs and lesion locations, potentially improving diagnostic accuracy and standardizing breast MRI protocols in clinical practice.
Zhao et al. (Tue,) studied this question.
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