Motivation: There is a pressing clinical need to distinguish aggressive from indolent prostate cancer (PCa). Goal(s): This study's objective was to quantify the capability of Hyperpolarized (HP) 1-13Cpyruvate magnetic resonance imaging (MRI) to distinguish aggressive from indolent PCa. Approach: A prospectively enrolled patient cohort underwent 3T multiparametric 1H/HP13C MRI followed by prostatectomy and whole-mount histopathology. Multivariate logistic regression was performed to classify lesions. Results: Statistically significant differences for imaging parameters were observed between low-grade and high-grade PCa. The multivariate model including kPL, ADC, and DCE enhancement slope (ES) predicted aggressive disease with a ROC area under curve = 0.93. Impact: There is a pressing clinical need to distinguish aggressive from indolent prostate cancer (PCa). Hyperpolarized 1-13Cpyruvate magnetic resonance imaging in combination with 1H multiparametric MRI has demonstrated potential to identify aggressive disease with high accuracy.
Gibbons et al. (Tue,) studied this question.
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