Motivation: The role of MRSI in predicting 5-ALA fluorescence in gliomas has not yet been explored. Goal(s): Our goal was to test if 7T MRSI is able to predict the presence of 5-ALA fluorescence and to compare it to CE MRI and PET. Approach: We retrospectively evaluated 5-ALA fluorescence, 7T MRSI ratio levels, PET TNRs and T1w-CE in 30 glioma patients. Further, we tested their abilities to predict 5-ALA fluorescence using ROC curves. Results: ROC curves indicate that Gln/tCr, Gly/tCr, Ser/tCr and GSH/tCr have the potential to predict 5-ALA fluorescence, with performance comparable to CE and PET. Impact: Our results show that 7T MRSI is a powerful tool for predicting 5-ALA fluorescence in gliomas and can be useful in therapy planning. It would be valuable to investigate the spatial correlation between 7T MRSI and areas of 5-ALA fluorescence.
Huskić et al. (Tue,) studied this question.