Motivation: Liver T1 can vary with inflammation/fibrosis, and with PDFF. Differentiating these may provide additional insight into disease progression. Goal(s): To develop and assess a chemical shift-encoded (CSE) MOLLI technique that enables simultaneous estimation of water-specific T1 and PDFF in a single breath-hold. Approach: This study included asymptomatic individuals and participants with steatotic and non-steatotic liver diseases. Imaging included six-echo CSE MRI (mDIXON Quant®), single-echo MOLLI with fat suppression (FS), and CSE MOLLI. Results: CSE MOLLI-derived T1-W and PDFF correlated very strongly with FS MOLLI (r = 0.93) and mDIXON Quant (r = 0.99) in 20 participants (PDFF median: 4.8%, range: 0.2-44.3%). Impact: This study introduces a single breath-hold CSE MOLLI technique that simultaneously estimates water-specific T1 and fat fraction in the liver, showing strong correlations with established methods. This approach aids in differentiating the impacts of water and fat on liver health.
Greer et al. (Tue,) studied this question.
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