What type of study is this?

This is a Quantitative Study study.

September 17, 2025

CEST perspectives for human brain applications at 11.7 T

Key Points

Optimized CEST pulses at 11.7 T show greater inhomogeneity compared to 7 T, impacting imaging quality.
B1+ maps acquired on a human head phantom revealed enhanced benefits of parallel transmission techniques.
The study investigates the application of CEST imaging using customized pulses under various energy management strategies.
Implications of using a higher magnetic field like 11.7 T for clinical CEST evaluations present exciting opportunities.

Abstract

Motivation: High magnetic field CEST imaging presents unique opportunities for clinical applications development. Goal(s): To investigate the potential of human brain CEST imaging on the 11.7 T scanner using tailored parallel transmission CEST pulses and compare performances with those of 7 T. Approach: 7 T and 11.7 T B1+ maps were acquired on a realistic human head phantom and pTx CEST pulses were designed for a targeted B1+ value under different energy management strategies. Results: At 11.7 T, the optimized CEST pulses exhibit more inhomogeneity than at 7 T. pTx and VOPs are highly beneficial, with best homogeneity obtained for hydroxyl-weighted maps. Impact: This study explores the potential of using the 11.7 T scanner for human brain CEST applications, addressing B1+ inhomogeneities and SAR compliance. It marks a first step toward clinical evaluation of CEST at magnetic fields higher than 7 T.

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