What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Repeatability of simultaneous 1H/23Na MR fingerprinting in knee cartilage at 7 T

Key Points

Good repeatability (CV around 10%) was observed for proton T1 and sodium density, supporting consistent measurements.
Findings include higher CV for parameters like proton density and sodium T2s, indicating variability in some metrics.
Four 3D acquisitions were conducted on six volunteers, highlighting robust imaging methods at 7T for knee cartilage analysis.
The results suggest potential for future applications in assessing knee pathologies using simultaneous MRF techniques.

Abstract

Motivation: Simultaneous 1H/23Na MRF has potential for assessing pathologies in the knee cartilage. Goal(s): This pilot study aims to evaluate the repeatability of simultaneous 1H/23Na MR fingerprinting (MRF) in knee cartilage of healthy subjects, to establish a baseline for spin densities and relaxation times. Approach: We conducted four 3D 1H/23Na MRF acquisitions in six volunteers using a dual-tuned knee coil at 7T, obtaining sodium and proton maps through offline image reconstruction and MRF dictionary matching. Results: The findings reveal good repeatability (CV around 10%) for proton T1, sodium density, T1, and T2l, while higher CV was observed in proton density, T1 and sodium T2s. Impact: This is the first simultaneous acquisition of multinuclear MRF in knee cartilage at 7T. The pilot study indicates repeatability of measuring sodium and proton spin densities and relaxation times.

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