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October 3, 2025

Enantioselective Synthesis of Atropisomeric 3-Arylindoles via Cobalt-Catalyzed Electroreductive Cross-Coupling

SXShi-Shuo XuShanghai Institute of Organic Chemistry JGJianfeng GuoChinese Academy of Sciences CMCong MaShenzhen University

Key Points

Cobalt-catalyzed synthesis achieves high enantioselectivity, enabling efficient production of 3-arylindoles.
The approach exhibits mild conditions, expanding its application to a broader range of substrates.
This strategy resolves challenges with indole substrates lacking electron-withdrawing groups at the 2-position.
The method's versatility allows for the use of diverse aryl iodides and indole bromides in the cross-coupling reaction.

Abstract

Cobalt-catalyzed enantioselective electroreductive cross-coupling of aryl iodides and indole bromides has been developed. This strategy is characterized by mild reaction conditions, high enantioselectivities, and a broad substrate scope. Notably, this approach effectively addresses the challenges associated with indole substrates that do not possess electron-withdrawing substituents at the 2-position, a limitation that remains unresolved in other strategies.

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