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This is a Quantitative Study study.

October 3, 2025Open Access

Optimizing Xenon 129 Ventilation MRI in Cystic Fibrosis with Spiral Imaging and Flip-Angle Correction

Key Points

Faster and more precise xenon 129 ventilation MRI was achieved in cystic fibrosis patients using new methods.
Keyhole-based flip-angle correction significantly enhanced the acquisition process by aligning it with normative data.
Two-dimensional spiral acquisition facilitated quicker imaging while maintaining high accuracy and reliability.
Findings suggest the dual approach may lead to better monitoring of lung function in cystic fibrosis patients.

Abstract

Faster and more accurate xenon 129 ventilation MRI was achieved in individuals with cystic fibrosis by combining two-dimensional spiral acquisition, keyhole-based flip-angle correction, and median-anchored generalized linear binning calibrated to normative data from healthy controls.

Optimizing Xenon 129 Ventilation MRI in Cystic Fibrosis with Spiral Imaging and Flip-Angle Correction

Key Points

Abstract

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