Aims: Lung cancer remains the leading cause of cancer-related mortality worldwide, with especially poor outcomes in the metastatic stage. Liver metastases and subsequent liver failure significantly worsen prognosis. Accurate risk stratification is therefore essential in this setting. The albumin-bilirubin (ALBI) score, a simple and objective indicator of liver function, may aid in prognostic evaluation. Unlike previous studies, this study specifically focuses on lung cancer patients with liver failure, a clinically distinct and high-risk subgroup. Methods: Clinicopathological data and laboratory parameters were retrospectively retrieved from the hospital information system for patients with histologically confirmed lung cancer and concurrent liver metastases complicated by liver failure. ALBI score was calculated based on peripheral blood test results using the formula: (0.66×log10bilirubin, μmol/L)−(0.085×albumin, g/L). Results: The median overall survival (mOS) was 0.19 months in ALBI grade 3 (95% CI: 0.10–0.28) and 1.54 months in ALBI grade 2 (95% CI: 0.19–2.89), with a statistically significant difference (p
Yaşar et al. (Mon,) studied this question.