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Potent therapeutic effects of patient’s PBMC-derived 7 × 19 CAR-T in autologous pancreatic cancer organoids. A, Tumor mass was established in NOG-ΔMHC by subcutaneous inoculation with 1 × 106 pancreatic cancer organoids. After 88 days, the established tumor mass was resected and examined for HER2 expression by IHC staining. B and C, NOG-ΔMHC mice were inoculated subcutaneously with 1 × 106 pancreatic cancer organoids on day 0 and then treated with intravenous injection of 5 × 106 anti-HER2 Conv. CAR-T or 7 × 19 CAR-T cells on day 10 or (left) untreated. Thereafter, the tumor size (B) and the mouse survival (C) were assessed (n = 5 each in all groups, biological replicates). **, P P
Ohta et al. (Wed,) studied this question.