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Abstract The number of survivors of head and neck squamous cell carcinoma (HNSCC) in the United States is expected to rise in coming years due to higher quality and more accessible cancer care, diminished smoking and alcohol consumption rates, and increased frequency of less aggressive human papillomavirus (HPV)-associated oropharyngeal cancers. In developed nations, about 80% of HNSCC patients are current smokers, recent quitters (within the past year), and former smokers. About 39% of HNSCC patients living in the United States say that they are current drinkers, drinkers who exceed moderate levels, and binge drinkers. Of all HNSCC cases, between 72% and 80% are associated with specifically tobacco use, alcohol use, or the two. Tobacco use and alcohol consumption have been shown to be predictive for HNSCC diagnosis and survival. However, the underlying trends and social determinants linking HNSCC survival to tobacco use and alcohol consumption are poorly understood. To reach a better understanding, data will be sourced from the National Health Interview Survey from 2010 to 2021, adjusted for age and other confounders, and then analyzed with Cox proportional hazards regression analysis. The results will inform a deeper understanding of the connections between HNSCC survival and tobacco and alcohol use and can point to new approaches and treatment targets for patient care. Citation Format: Rashad Rahman, Meng Chen, Nosayaba Osazuwa-Peters. Association between head and neck squamous cell carcinoma survival, tobacco use, and alcohol use, 2010-2021 abstract. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A094.
Rahman et al. (Sat,) studied this question.