We study the design of adaptive, sequential experiments for unbiased average treatment effect (ATE) estimation in the design-based potential outcomes setting. Our goal is to develop adaptive designs offering sublinear Neyman regret, meaning their efficiency must approach that of the hindsight-optimal nonadaptive design. Recent work Dai et al, 2023 introduced ClipOGD, the first method achieving O (T) expected Neyman regret under mild conditions. In this work, we propose adaptive designs with substantially stronger Neyman regret guarantees. In particular, we modify ClipOGD to obtain anytime O (T) Neyman regret under natural boundedness assumptions. Further, in the setting where experimental units have pre-treatment covariates, we introduce and study a class of contextual "multigroup" Neyman regret guarantees: Given any set of possibly overlapping groups based on the covariates, the adaptive design outperforms each group's best non-adaptive designs. In particular, we develop a contextual adaptive design with O (T) anytime multigroup Neyman regret. We empirically validate the proposed designs through an array of experiments.
Noarov et al. (Mon,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: