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Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability to convert vitamin D into the active form of calcitriol, which is crucial for controlling cell inflammation. Low vitamin D levels are associated with increased inflammation and higher levels of biomarkers such as c-reactive protein and asymmetric dimethylarginine as an endogenous inhibitor of nitric oxide synthase. Those two combined become a specific marker for cardiovascular diseases, which become one of the common causes of CKD mortality. Objective: This study examines the correlation between vitamin D insufficiency, elevated high-sensitivity c-reactive protein, and asymmetric dimethylarginine in CKD patients receiving hemodialysis. Methods: This study used a cross-sectional design of CKD patients receiving hemodialysis in Dr. Kariadi Central General Hospital, Semarang, Indonesia, in November 2021. Thirty-six patients were randomly enrolled after meeting inclusion and exclusion criteria. Primary outcomes of Vitamin D, hs-CRP, and ADMA were measured from patients’ blood after hemodialysis. A statistical analysis of Pearson's correlation was used for primary outcomes. Results: No significant difference was found in the patient's baseline characteristics. A significant correlation between vitamin D and ADMA has been found; however, no correlation between vitamin D and hs-CRP has been found Conclusion: Vitamin D deficiency is correlated with elevated ADMA, indicative of endothelial dysfunction.
Lusito et al. (Sat,) studied this question.