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Background Gut-brain axis: One of the major bidirectional interaction between central and peripheral nervous system and gastrointestinal tract. More recent studies have highlighted the fact that alterations in the balance of the gut microbiota can affect this axis and predispose the individual to functional gastrointestinal disorders (FGIDs) such as irritable bowel syndrome (IBS). Objectives: To examine the effects of intestinal microbiota in moderating the influence of the gut-brain axis to the pathogenesis of IBS. Study design: A cross-sectional study Place and duration of study: Medicine Department of Ayub Teaching Hospital- Abbottabad, from Jan 2022 to Jan 2023. Methods: Of the various patients involved in this study, 150 were diagnosed with IBS. Fecal samples were collected to evaluate the intestinal bacterial flora, and psychological tests were taken to know the level of stress and anxiety. The correlation that was performed for the microbial diversity and IBS symptoms involved the use of p-value as well as the standard deviation. Results: Patient mean age was 38. 4 (SD = 10. 2) years. A massive decrease in microbiological heterogeneity was recorded in the IBS patients 60% (p=0. 004). Among the IBS patients, those who report more significant levels of anxiety and stress had a more profound dysbiosis and greater IBS symptom severity (p = 0. 002). Logically, and when comparing the two groups, direct statistics pointed at the fact that lower microbial richness was linked with greater symptom severity of IBS. Conclusion: This paper looks at the evidence connecting alterations in the host's gut microbial composition with the onset and persistence of IBS. IBS is related to the dysfunction of gut-brain axis, and the altered gut microbiota is considered to be involved in the pathogenesis of IBS, so the microbial intervention may be effective in the treatment of IBS.
Nimra Tul Ain Khan (Sat,) studied this question.