Efficacy of Anogeissus leiocarpus as a Therapeutic Agent for Some Pathogenic Bacteria

BACKGROUND: This study examines the folkloric potential of the leaf extract of Angogeissus leocarpus_ and it is aimed at the effectiveness for possible treatment of infections caused by some pathogenic bacteria. METHODOLOGY: Solvent extract of the leaf of A_. ₗeocarpus_ was processed for phytochemical and antibacterial effects. Clinical and type bacterial cultures were tested for susceptibility to the quotes. RESULTS: The phytochemicals screened from the ethanol leaf extract were saponin, flavonoids, steroids, alkaloids, tannins, glycosides and phlobatannins while from the aqueous extract, it was flavonoids, tannins, saponin and steroids. The ethanol leaf extract provided the higher bioactive compounds for inhibition (10-36 mm) of the tested bacteria species. The aqueous leaf extract inhibited the bacteria species with zones that ranged from 10-25 mm. The ethanol leaf extract's minimum inhibitory concentration (MIC) was effective at 12. 5 mg/mL and minimum bactericidal concentration (MBC) at 50 mg/mL. The aqueous MIC was effective with the 50 mg/mL concentration and MBC with the 100 mg/mL concentration. Promising values were recorded in the proximate and mineral contents analyzed. The hydroxyl radical scavenging values of the ethanol and aqueous extracts are 0. 56±0. 60 and 73±0. 4, FRAP (1. 86±0. 11 and 1. 24±0. 2), DPPH (1. 79±1. 3 and 1. 61±0. 1) mg of ascorbic acid/1 g dry leaves sample respectively. CONCLUSION: A_. ₗeiocarpus_ extracts effective in bacteria inhibition and nutrition could be a good source for drug development to treat diseases hence it could have a space of recognition among the few medicinal plants which have been studied for their medical properties with novel therapeutic values.