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We assessed the whole-brain oxygen metabolism perturbations in AD using QSM and quantitative BOLD. mGRE data and QQ model was employed to calculate OEF and ASL data was used to reconstruct CBF map. The CMRO2 can be estimated from CBF and OEF based on Fick’s principle. Our results demonstrated a characteristic whole-brain hypoperfusion and hypometabolism pattern in AD, predominantly located within default-mode network. Additionally, decreased CBF and CMRO2 in substructures of bilateral hippocampus strongly correlated with global cognition. QQ model-based noninvasively quantitative measurements have a great potential to be complementary biomarkers for evaluating cognitive impairment in AD.
Yang et al. (Wed,) studied this question.