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Myocardial T1 reactivity, defined as the relative T1 change from rest to stress, has been proposed as a marker for detection of ischemic heart disease. SASHA-based T1 mapping provides higher accuracy than MOLLI, but the scan time can be prohibitive under stress. In this work, we investigated the feasibility of accelerated SASHA T1 mapping for ferumoxytol-enhanced dobutamine-stress T1 reactivity studies at 3T in a preclinical setting. We showed that a 2-fold accelerated SASHA T1 mapping can provide sufficiently accurate results compared to conventional SASHA.
Unal et al. (Wed,) studied this question.