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In 16 healthy adults, we examined the correlation between three MR myelin measurement methods, including myelin volume fraction (MVF) measured with simultaneous tissue relaxometry of R1 and R2 relaxation rates and proton density, inhomogeneous magnetization transfer imaging (ihMT), and myelin water fraction (MWF). A strong correlation was obtained between ihMT and MVF, and MWF was less correlated with the others. We should be mindful that these metrics are measuring different aspects of “myelin”.
Nakaya et al. (Wed,) studied this question.