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Following hyperpolarized 1-13Cpyruvate MRI studies that demonstrated insights into brain metabolism using saturation experiments, this study sought to assess whether metabolic pathways probed by 2-13Cpyruvate could similarly be interrogated. Our investigation showed that not exciting 2-13Clactate led to a 2-fold increase in 5-13Cglutamate signal, which may indicate compartmentalized metabolism in the brain.
Autry et al. (Wed,) studied this question.