Key points are not available for this paper at this time.
Alzheimer’s disease (AD) is characterised by many pathophysiological changes, such as the accumulation of amyloid-β. The clearing of detrimental agents, including amyloid-β proteins, from brain tissue is linked to the function of choroid plexus (CP) or blood-cerebrospinal fluid barrier (BCSFB). This study investigates for the first time BCSFB function using non-invasive ASL-based methods in a mouse model of AD. Significantly higher values of total BCSFB-mediated water delivery in AD mice relative to controls were observed as early as 8 weeks of age, and a possible (though currently non-significant) correlation with behavioural tests was identified.
Perera et al. (Wed,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: