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The glymphatic system seems to be involved to protect the brain pathologies like Alzheimer’s disease, by the clearance of brain waste1. A previous study showed the apparent diffusion coefficients (ADC) in several brain regions were increased by aquaporin 4 (AQP4) inhibitor2. However, the time course of ADC change has not been investigated. In this study, we showed the time course of ADC change in multiple mouse brain regions following injection of the TGN020 and the effect of TGN020 on volume-dependent intrinsic optical signals in brain slices.
Tsurugizawa et al. (Wed,) studied this question.