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Hyperpolarized 13C MRS was used to measure human brain pH for the first time following 13C imaging through measurements of 13CO2 and bicarbonate. Aspartate concentration was also found offering insight into amino acid metabolism. Global brain pH was measured in the brain to be 6.98 ± 0.06. Non-invasive measurements of cerebral pH could be particularly important in assessing cerebral pathology given the wide range of disease processes that alter acid-base balance. Aspartate was measured in 4 of 9 volunteers with no age-related trends seen. Pyruvate carboxylase flux was found to be 6% of pyruvate dehydrogenase flux.
Khan et al. (Wed,) studied this question.
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