Assessment of Pulmonary Morphometry using Hyperpolarized 129Xe DWI with Variable-Sampling-Ratio Compressed Sensing Patterns

The long acquisition time of hyperpolarized 129Xe multiple b-values DWI made it hard to apply in patients with severe pulmonary diseases. Herein, we proposed a method of variable-sampling-ratio compressed sensing patterns for accelerating hyperpolarized 129Xe DWI. A four-fold reduction in acquisition time was achieved using the proposed method while preserving good image quality. Meanwhile, the method can be used for evaluating pulmonary injuries caused by cigarette smoking.